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Rosanna Arquette's indie film sensibility and emotional honesty made her a favorite of independent directors in films like 'Desperately Seeking Susan' and 'After Hours' where her natural vulnerability created compelling characters. Her willingness to take risks in unconventional projects established her as one of the most adventurous actresses of the 1980s. The combination of mainstream appeal and art house credibility allowed her to bridge different types of filmmaking throughout her career.